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ANS Binding Reveals Common Features of Cytotoxic Amyloid Species

Bolognesi, Benedetta, Kumita, Janet R., Barros, Teresa P., Esbjorner, Elin K., Luheshi, Leila M., Crowther, Damian C., Wilson, Mark R., Dobson, Christopher M., Favrin, Giorgio, Yerbury, Justin J.

Journal:

ACS Chemical Biology

Année:

2010

Langue:

english

Fichier:

PDF, 2.30 MB

english, 2010

Endoplasmic reticulum dysfunction in neurological disease

Benoit D Roussel, Antonina J Kruppa, Elena Miranda, Damian C Crowther, David A Lomas, Stefan J Marciniak

Journal:

The Lancet Neurology

Année:

2013

Langue:

english

Fichier:

PDF, 598 KB

english, 2013

CCT complex restricts neuropathogenic protein aggregation via autophagy

Pavel, Mariana, Imarisio, Sara, Menzies, Fiona M., Jimenez-Sanchez, Maria, Siddiqi, Farah H., Wu, Xiaoting, Renna, Maurizio, O’Kane, Cahir J., Crowther, Damian C., Rubinsztein, David C.

Journal:

Nature Communications

Année:

2016

Langue:

english

Fichier:

PDF, 3.86 MB

english, 2016

Familial conformational diseases and dementias

Damian C. Crowther

Journal:

Human Mutation

Année:

2002

Langue:

english

Fichier:

PDF, 248 KB

english, 2002

Serpins: Implications of a mobile reactive centre

Damian C. Crowther, Dyfed L.I. Evans, Robin W. Carrell

Journal:

Current Opinion in Biotechnology

Année:

1992

Langue:

english

Fichier:

PDF, 924 KB

english, 1992

Protein misfolding and disease: from the test tube to the organism

Leila M Luheshi, Damian C Crowther, Christopher M Dobson

Journal:

Current Opinion in Chemical Biology

Année:

2008

Langue:

english

Fichier:

PDF, 422 KB

english, 2008

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

Thomas R. Jahn, Kai J. Kohlhoff, Michael Scott, Gian Gaetano Tartaglia, David A. Lomas, Christopher M. Dobson, Michele Vendruscolo, Damian C. Crowther

Journal:

Journal of Neuroscience Methods

Année:

2011

Langue:

english

Fichier:

PDF, 708 KB

english, 2011

Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers : Implications for the epilepsy seen in the dementia FENIB

Didier Belorgey, Lynda K. Sharp, Damian C. Crowther, Maki Onda, Jan Johansson, David A. Lomas

Journal:

FEBS Journal

Année:

2004

Langue:

english

Fichier:

PDF, 368 KB

english, 2004

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a Drosophila model of Alzheimer’s disease

Thomas Rival, Richard M. Page, Dhianjali S. Chandraratna, Timothy J. Sendall, Edward Ryder, Beinan Liu, Huw Lewis, Thomas Rosahl, Robert Hider, L. M. Camargo, Mark S. Shearman, Damian C. Crowther, D

Journal:

European Journal of Neuroscience

Année:

2009

Langue:

english

Fichier:

PDF, 617 KB

english, 2009

The management of primary fallopian tube carcinoma

HOWARD GURNEY, DAMIAN MURPHY, DEREK CROWTHER

Journal:

BJOG: An International Journal of Obstetrics & Gynaecology

Année:

1990

Langue:

english

Fichier:

PDF, 332 KB

english, 1990

Unravelling the twists and turns of the serpinopathies

Benoit D. Roussel, James A. Irving, Ugo I. Ekeowa, Didier Belorgey, Imran Haq, Adriana Ordóñez, Antonina J. Kruppa, Annelyse Duvoix, Sheikh Tamir Rashid, Damian C. Crowther, Stefan J. Marciniak, David

Journal:

FEBS Journal

Année:

2011

Langue:

english

Fichier:

PDF, 320 KB

english, 2011

Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies

Crowther, Damian C, Belorgey, Didier, Miranda, Elena, Kinghorn, Kerri J, Sharp, Lynda K, Lomas, David A

Journal:

European Journal of Human Genetics

Année:

2003

Langue:

english

Fichier:

PDF, 159 KB

english, 2003

Alzheimer's disease: insights from Drosophila melanogaster models

Aileen Moloney, David B. Sattelle, David A. Lomas, Damian C. Crowther

Journal:

Trends in Biochemical Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 2.60 MB

english, 2010

Prion-induced toxicity in PrP transgenic Drosophila

Alana M. Thackray, Farooq Muhammad, Chang Zhang, Margaret Denyer, John Spiropoulos, Damian C. Crowther, Raymond Bujdoso

Journal:

Experimental and Molecular Pathology

Année:

2012

Langue:

english

Fichier:

PDF, 898 KB

english, 2012

Therapeutic targets from a Drosophila model of Alzheimer’s disease

Damian C Crowther, Kerri J Kinghorn, Richard Page, David A Lomas

Journal:

Current Opinion in Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 105 KB

english, 2004

Characterisation of serpin polymers in vitro and in vivo

Didier Belorgey, James A. Irving, Ugo I. Ekeowa, Joanna Freeke, Benoit D. Roussel, Elena Miranda, Juan Pérez, Carol V. Robinson, Stefan J. Marciniak, Damian C. Crowther, Claire H. Michel, David A. Lom

Journal:

Methods

Année:

2011

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2011

P1-111: Using a Drosophila model of Alzheimer’s disease to identify genetic modifiers of Ab1-42-induced oxidative stress

Thomas Rival, Damian C. Crowther, Page Richard, Ryder Ed, Bautista-Llacer Rosa, Lomas A. Lomas

Journal:

Alzheimer's & Dementia

Année:

2006

Langue:

english

Fichier:

PDF, 59 KB

english, 2006

P1-082: Using a Drosophila model of Alzheimer’s disease to direct the search for genetic modifiers of Aβ1-42 neurotoxicity

Richard Page, Damian C. Crowther, Dhia Chandraratna, Ed Ryder, Rosa Bautista-Llacer, David A. Lomas

Journal:

Alzheimer's & Dementia

Année:

2006

Langue:

english

Fichier:

PDF, 65 KB

english, 2006

Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis

Lynda K. Sharp, Meera Mallya, Kerri J. Kinghorn, Zhen Wang, Damian C. Crowther, James A. Huntington, Didier Belorgey, David A. Lomas

Journal:

FEBS Journal

Année:

2006

Langue:

english

Fichier:

PDF, 347 KB

english, 2006

Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival

Thackray, Alana M., Muhammad, Farooq, Zhang, Chang, Di, Ying, Jahn, Thomas R., Landgraf, Matthias, Crowther, Damian C., Evers, Jan Felix, Bujdoso, Raymond

Journal:

Biochemical Journal

Année:

2012

Langue:

english

Fichier:

PDF, 586 KB

english, 2012

Testing the Therapeutic Potential of Doxycycline in a Drosophila melanogaster model of Alzheimer's Disease

Costa, Rita, Speretta, Elena, Saraiva, Maria João, Crowther, Damian C., Cardoso, Isabel

Journal:

Alzheimer's & Dementia

Année:

2011

Langue:

english

Fichier:

PDF, 50 KB

english, 2011

Puromycin-sensitive aminopeptidase rescues β-amyloid toxicity in Alzheimer's disease

Kruppa, Antonina, Chandraratna, Dhia, Irving, James, Marciniak, Stefan, Townsend, Matthew, Crowther, Damian, Lomas, David

Journal:

Alzheimer's & Dementia

Année:

2011

Langue:

english

Fichier:

PDF, 52 KB

english, 2011

BRICHOS efficiently inhibits beta-amyloid 42 aggregation and toxicity in Drosophila melanogaster

Hermansson, Erik, Loganathan, Krishnapriya, Crowther, Damian, Westermark, Gunilla, Winblad, Bengt, Johansson, Jan, Presto, Jenny

Journal:

Alzheimer's & Dementia

Année:

2013

Langue:

english

Fichier:

PDF, 68 KB

english, 2013

An RNAI screen for genes that modify human amyloid induced paralysis in caenorhabditis elegans facilitates functional analysis of candidate risk factors for Alzheimer's disease

M. Moloney, Aileen, Fraboulet, Sandrine, Link, Christopher D., Williams, Julie, Lomas, David A., Crowther, Damian, Sattelle, David B.

Journal:

Alzheimer's & Dementia

Année:

2009

Langue:

english

Fichier:

PDF, 43 KB

english, 2009

Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies

Wacker, Jessica, Rönicke, Raik, Westermann, Martin, Wulff, Melanie, Reymann, Klaus G, Dobson, Christopher M, Horn, Uwe, Crowther, Damian C, Luheshi, Leila M, Fändrich, Marcus

Journal:

Acta Neuropathologica Communications

Année:

2014

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2014

Retro-inversal of Intracellular Selected β-Amyloid-Interacting Peptides: Implications for a Novel Alzheimer’s Disease Treatment

Acerra, Nicola, Kad, Neil M., Griffith, Douglas A., Ott, Stanislav, Crowther, Damian C., Mason, Jody M.

Journal:

Biochemistry

Année:

2014

Langue:

english

Fichier:

PDF, 5.66 MB

english, 2014

Nucleation of α 1 -Antichymotrypsin Polymerization †

Crowther, Damian C., Serpell, Louise C., Dafforn, Timothy R., Gooptu, Bibek, Lomas, David A.

Journal:

Biochemistry

Année:

2003

Langue:

english

Fichier:

PDF, 259 KB

english, 2003

The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster

Kohlhoff, Kai J., Jahn, Thomas R., Lomas, David A., Dobson, Christopher M., Crowther, Damian C., Vendruscolo, Michele

Journal:

Integrative Biology

Année:

2011

Langue:

english

Fichier:

PDF, 1.79 MB

english, 2011

[Methods in Enzymology] Amyloid, Prions, and Other Protein Aggregates, Part B Volume 412 || A Drosophila Model of Alzheimer's Disease

Crowther, Damian C.

Année:

2006

Langue:

english

Fichier:

PDF, 218 KB

english, 2006

Blockade of the suprascapular nerve: a radiological and cadaveric study comparing landmark and ultrasound-guided blocking techniques

Lancaster, Sarah T., Clark, Damian A., Redpath, Yvette, Hughes, David M., Crowther, Mark A., Lewis, Simon M.

Journal:

Shoulder & Elbow

Année:

2013

Langue:

english

Fichier:

PDF, 957 KB

english, 2013

Systematic In Vivo Analysis of the Intrinsic Determinants of Amyloid β Pathogenicity

Luheshi, Leila M., Tartaglia, Gian Gaetano, Brorsson, Ann-Christin, Pawar, Amol P., Watson, Ian E., Chiti, Fabrizio, Vendruscolo, Michele, Lomas, David A., Dobson, Christopher M., Crowther, Damian C.

Journal:

PLoS Biology

Année:

2007

Langue:

english

Fichier:

PDF, 554 KB

english, 2007

Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

Luheshi, Leila M., Hoyer, Wolfgang, de Barros, Teresa Pereira, van Dijk Härd, Iris, Brorsson, Ann-Christin, Macao, Bertil, Persson, Cecilia, Crowther, Damian C., Lomas, David A., Ståhl, Stefan, Dobson

Journal:

PLoS Biology

Année:

2010

Langue:

english

Fichier:

PDF, 625 KB

english, 2010

Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid β peptide toxicity

Ott, Stanislav, Vishnivetskaya, Anastasia, Malmendal, Anders, Crowther, Damian C.

Journal:

Neurobiology of Aging

Année:

2016

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2016

Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems

El-Khoury, Riyad, Kaulio, Eveliina, Lassila, Katariina A, Crowther, Damian C, Jacobs, Howard T, Rustin, Pierre

Journal:

Free Radical Biology and Medicine

Année:

2016

Langue:

english

Fichier:

PDF, 572 KB

english, 2016

AN ASSAY FOR SEEDED PROTEIN AGGREGATION DETECTS ABETA SEEDS IN SERUM

Crowther, Damian Christopher, van Vliet, Liisa, Kuhaudomlarp, Sue, Gielen, Fabrice, Yan, Jing, Azhar, Mayida, Hinault, Marie-Pierre, Hollfelder, Florian

Journal:

Alzheimer's & Dementia

Année:

2014

Langue:

english

Fichier:

PDF, 160 KB

english, 2014

Disease, Diagnosis and Decisionsby Graham W. Bradley

Review by: Damian C. Crowther

Journal:

Journal of Medical Ethics

Année:

1995

Langue:

english

Fichier:

PDF, 569 KB

english, 1995

Neuroserpin Phenotypes in Transgenic Drosophila are Rescued by the Alzheimer's β-amyloid peptide: In Vitro and in Vivo Correlations

Crowther, Damian C., Belorgey, Didier

Journal:

Clinical Science

Année:

2002

Langue:

english

Fichier:

PDF, 119 KB

english, 2002

α 1 -Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

Ekeowa, Ugo I., Gooptu, Bibek, Belorgey, Didier, Hägglöf, Peter, Karlsson-Li, Susanna, Miranda, Elena, Pérez, Juan, MacLeod, Ian, Kroger, Heike, Marciniak, Stefan J., Crowther, Damian C., Lomas, David

Journal:

Clinical Science

Année:

2009

Langue:

english

Fichier:

PDF, 604 KB

english, 2009

Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer’s model

Khabirova, Eleonora, Chen, Ko-Fan, O’Neill, John S., Crowther, Damian C.

Journal:

Scientific Reports

Année:

2016

Langue:

english

Fichier:

PDF, 2.28 MB

english, 2016

Central and peripheral circadian clocks and their role in Alzheimer's disease

Chauhan, Ruchi, Chen, Ko-Fan, Kent, Brianne A., Crowther, Damian C.

Journal:

Disease Models & Mechanisms

Année:

2017

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2017

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer disease

Younan, Nadine D., Chen, Ko-Fan, Rose, Ruth-Sarah, Crowther, Damian C., Viles, John H.

Journal:

Journal of Biological Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 2.08 MB

english, 2018

Free Cholesterol Induces Higher β-Sheet Content in Aβ Peptide Oligomers by Aromatic Interaction with Phe19

Zhou, Xiaolin, Xu, Jie, Crowther, Damian Christopher

Journal:

PLoS ONE

Année:

2012

Langue:

english

Fichier:

PDF, 1.45 MB

english, 2012

The Roles of Helix I and Strand 5A in the Folding, Function and Misfolding of α1-Antitrypsin

Knaupp, Anja S., Keleher, Shani, Yang, Li, Dai, Weiwen, Bottomley, Stephen P., Pearce, Mary C., Crowther, Damian Christopher

Journal:

PLoS ONE

Année:

2013

Langue:

english

Fichier:

PDF, 319 KB

english, 2013

Effect of Alanine Replacement of L17 and F19 on the Aggregation and Neurotoxicity of Arctic-Type Aβ40

Chen, Yi-Ru, Huang, Hsien-bin, Lo, Chi-Jen, Wang, Chih-Ching, Ho, Li-Kang, Liu, Hsin-Tzu, Shiao, Ming-Shi, Lin, Ta-Hsien, Chen, Yi-Cheng, Crowther, Damian Christopher

Journal:

PLoS ONE

Année:

2013

Langue:

english

Fichier:

PDF, 5.54 MB

english, 2013

The TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in Aβ-Expressing Caenorhabditis elegans

Khabirova, Eleonora, Moloney, Aileen, Marciniak, Stefan J., Williams, Julie, Lomas, David A., Oliver, Stephen G., Favrin, Giorgio, Sattelle, David B., Crowther, Damian C., Iijima, Koichi M.

Journal:

PLoS ONE

Année:

2014

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2014

Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting

Fabre, Kristin M., Delsing, Louise, Hicks, Ryan, Colclough, Nicola, Crowther, Damian C., Ewart, Lorna

Journal:

Advanced Drug Delivery Reviews

Année:

2018

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2018